The advent of single cell RNA sequencing makes the research aimed at unmasking the biological complexities driven by cellular heterogeneity possible, shedding new light on an underappreciated universe of cellular biology. The advanced GEM-X technology from 10x Genomics, featuring optimized reagents, improved microfluidic chip architecture, and upgraded analysis software, enables more sensitive, robust, and higher throughput Single Cell Gene Expression (3’) profiling.