Nick J. Proudfoot (NJP) is the Emeritus Professor of Molecular Biology at The
Sir William Dunn School of Pathology. Professor Nick discovered the mammalian polyadenylation signal (PAS) AAUAAA in the 1970s. At Oxford, his lab revealed that pre-mRNA 3′ end processing occurs co-transcriptionally, driving RNA polymerase II (Pol II) termination and showing that capping, splicing, cleavage, polyadenylation and RNA modifications all happen during transcription. With James L. Manley, he proposed the torpedo model and later identified XRN2 as key to Pol II termination. NJP also uncovered transcriptional interference (TI), linked to cancer and viral infection. Using tools like mNET-seq and POINT-seq, his lab established PAS as central to mammalian gene expression and explored long non-coding RNAs.